Handbook of drug screening
A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell...
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| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York
Marcel Dekker
2001
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| Series: | Drugs and the pharmaceutical sciences
v. 114 |
| Subjects: | |
| Online Access: | Click Here to View Status and Holdings. |
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| 245 | 0 | 0 | |a Handbook of drug screening |c edited by Ramakrishna Seethala, Prabhavathi B. Fernandes |
| 264 | # | 1 | |a New York |b Marcel Dekker |c 2001 |
| 264 | # | 4 | |c ©2001 |
| 300 | # | # | |a xiii, 597 pages |b illustrations |c 24 cm |
| 336 | # | # | |a text |b txt |2 rdacontent |
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| 338 | # | # | |a volume |b nc |2 rdacarrier |
| 490 | 1 | # | |a Drugs and the pharmaceutical sciences |v v. 114 |
| 504 | # | # | |a Includes bibliographical references and index |
| 505 | 0 | # | |a Moving into the third millennium after a century of screening -- Basic considerations in designing high-throughput screening assays -- Screening platforms -- Homogeneous assays for high-throughput and ultrahigh-throughput screening -- Microbe-based screening systems -- Molecular genetic screen design for agricultural and pharmaceutical product discovery -- Receptor screens for small molecule agonist and antagonist discovery -- Functional assay screens -- Enzyme screens -- Screening strategies for ion channel targets -- High-throughput screening assays for detection of transcription -- Screening of combinatorial biology libraries for natural products discovery -- Higher-throughput screening assays with human hepatocytes for hepatotoxicity, metabolic stability, and drug-drug interaction potential -- High-throughput screening for metabolism-based drug-drug interactions -- The ATCG of drug discovery -- Genomics/functional proteomics for identification of new targets -- Bioinformatics: identification of novel targets and their characterization -- The evolution of laboratory automation -- Robotics and automation -- Assay miniaturization: developing technologies and assay formats -- Screening in the NanoWorld: single-molecule spectroscopy and miniaturized high-throughput screening. |
| 520 | # | # | |a A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies |
| 650 | 1 | 2 | |a Drug Evaluation, Preclinical |x methods |
| 700 | 1 | # | |a Seethala, Ramakrishna |d 1947- |e editor |
| 700 | 1 | # | |a Fernandes, P. B. |e editor |
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Computer techniques in preclinical drug development