Handbook of drug screening

• Other Authors: Seethala, Ramakrishna 1947- (Editor), Fernandes, P. B. (Editor)
• Format: Book
• Language: English
• Published: New York Marcel Dekker 2001
• Series: Drugs and the pharmaceutical sciences v. 114
• Subjects: Drug Evaluation, Preclinical > methods
• Online Access: Click Here to View Status and Holdings.

A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell...

Table of Contents:

• Moving into the third millennium after a century of screening
• Basic considerations in designing high-throughput screening assays
• Screening platforms
• Homogeneous assays for high-throughput and ultrahigh-throughput screening
• Microbe-based screening systems
• Molecular genetic screen design for agricultural and pharmaceutical product discovery
• Receptor screens for small molecule agonist and antagonist discovery
• Functional assay screens
• Enzyme screens
• Screening strategies for ion channel targets
• High-throughput screening assays for detection of transcription
• Screening of combinatorial biology libraries for natural products discovery
• Higher-throughput screening assays with human hepatocytes for hepatotoxicity, metabolic stability, and drug-drug interaction potential
• High-throughput screening for metabolism-based drug-drug interactions
• The ATCG of drug discovery
• Genomics/functional proteomics for identification of new targets
• Bioinformatics: identification of novel targets and their characterization
• The evolution of laboratory automation
• Robotics and automation
• Assay miniaturization: developing technologies and assay formats
• Screening in the NanoWorld: single-molecule spectroscopy and miniaturized high-throughput screening.