Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis

• Main Author: Nurmazni Zulkafli (Author)
• Format: Thesis Book
• Language: English
• Published: Sungai Buloh, Selangor Universiti Teknologi MARA. Faculty of Medicine 2016
• Subjects: Endothelium > anatomy and histology; Tocotrienols > adverse effects; atherosclerosis > anatomy and histology
• Online Access: Click Here to View Status and Holdings.
• Item Description: UiTM Digitized
• Physical Description: xvii, 142 pages illustrations, charts (some colour) 30 cm 1 computer optical disc (4 ¾ in.)
• Format: System requirements for CD-ROM: Intel Pentium II or faster processor with 450 MHz (or equivalent), browser Internet Explorer 5.5 or higher (6.0 or higher recommended), Firefox 1.0.2 or higher, Acrobat
• Bibliography: Includes bibliographical references (page 106-127)

Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tissue endothelial activation and inflammatory biomarkers, and oxidative stress in early and established atherosclerosis rabbit model. Fifteen New Zealand white rabbits were divided into two intervention groups: Al [given 2 months normal diet (ND) and 2 weeks high cholesterol diet (HCD)] and A2 (given 2 months ND and 2 months HCD). Each group was further divided into three groups: T3- 4mg/kg and T3-15mg/kg supplementation groups given pure T3 (delta90%-gammal0%) and placebo. Interventions were given throughout the study. Fasting serum lipids, plasma C-reactive protein and 8-isoprostanes were measured at baseline, 4, 8, 10, 12, 16 weeks...