Human Reproductive and Prenatal Genetics

• Other Authors: Leung, P. C. K. (Editor), Qiao, Jie 1964 (Editor)
• Format: Book
• Language: English
• Published: London San Diego Academic Press 2019
• Subjects: Genitalia > embryology; Gametogenesis > genetics; Reproductive Techniques, Assisted; Preimplantation Diagnosis > methods
• Online Access: Click Here to View Status and Holdings.

Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwi...

Table of Contents:

• Intro; Title page; Table of Contents; Copyright; Contributors; Part I: Reproductive Tract Development and Gametogenesis; Chapter 1: Developmental Genetics of the Male Reproductive System; Abstract; Introduction; Early Testicular Development; Testicular Descent; Development of the External Genitalia; Birth Defects; Conclusion; Glossary; Chapter 2: Genetics and Genomics of Early Gonad Development; Abstract; Introduction; Molecular Physiology in Gonad Development; Essential Transcription Factors in Gonad Development; Conclusions; Chapter 3: Genetics of Meiotic Chromosome Dynamics and Fertility
• AbstractAcknowledgments; Overview and Scope; Meiosis and Its Regulation in Males and Females; Genetic Approaches to Study Meiosis; Meiotic Prophase Chromosome Dynamics: the Foundation of Meiosis; Meiotic Division Phases: The Culmination of Meiosis; Meiosis, Fertility, and Human Health; Summary and Perspectives; Chapter 4: Effects of Aging on Sperm Chromatin; Abstract; Acknowledgments; Introduction; Transformations of the Nucleus During Spermatogenesis; Aging and Male Germ Cells; Conclusion; Chapter 5: In Vitro Spermatogenesis From Pluripotent Stem Cells; Abstract; Introduction
• Induction of Spermatogenesis in MiceInduction of Spermatogenesis in Humans; Discussion; Chapter 6: Developmental Genetics of the Female Reproductive Tract; Abstract; Introduction; Embryogenesis of the Female Reproductive Tract; Fallopian Tube Anomalies; Uterine Anomalies; Cervical Anomalies; Development of the Vagina; Conclusion; Chapter 7: The Molecular Genetics of Oogenesis; Abstract; Acknowledgments; Introduction; Oogenesis: An Overview; Nuclear DNA (nDNA) Inheritance; Mitochondrial Inheritance; Summary; Chapter 8: Epigenetic Control of Oocyte Development; Abstract; Acknowledgments
• IntroductionEpigenetic Modifications in the Oocyte Genome; Establishment of DNA Methylation During Oocyte Growth; Histone Modifications During Oocyte Growth; Large-Scale Chromatin Remodeling in the Oocyte Genome; Heterochromatin Formation and Chromosome Stability During Oocyte Meiosis; Chromosome-Microtubule Interactions at the Kinetochore; Environmental and Hormonal Causes of Oocyte Aneuploidy; Conclusions; Chapter 9: RNA Binding Protein Networks and Translational Regulation in Oocytes; Abstract; Introduction; Oocyte Meiotic Maturation; Components of the Translational Program in Oocytes
• Biological Significance of the Translation Program in OocytesConclusions and Perspectives; Chapter 10: Translational Regulation of Gene Expression During Oogenesis and Preimplantation Embryo Development; Abstract; Introduction; Factors Determining Oocyte Transcriptome; Essential Regulatory Components of Translation in Somatic Cells; Translation Regulatory Pathways in Oocytes and Early Preimplantation Embryos; Translational Regulation in the Early Embryo; Conclusion; Chapter 11: MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications; Abstract; Acknowledgments; Introduction