Behavioral genetics of the mouse

• Other Authors: Crusio, W. E (Editor), Sluyter, Frans (Editor), Pietropaolo, Susanna (Editor)
• Format: Book
• Language: English
• Published: Cambridge Cambridge University Press 2013; ©2013
• Series: Cambridge handbooks in behavioural genetics
• Subjects: Mice > genetics; Genetics, Behavioral
• Online Access: Click Here to View Status and Holdings.
• Item Description: v. 1. Genetics of behavioral phenotypes / edited by Wim E. Crusio, Frans Sluyter, Robert T. Gerlai, Susanna Pietropaolo; v. 2. Genetic mouse models of neurobehavioral disorders / edited by Susanna Pietropaolo, Frans Sluyter, and Wim E. Crusio
• Physical Description: 2 volume illustrations 28 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9781107034815; 1107034817; 9781107044456; 1107044456

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike