Antibiotics targets, mechanisms and resistance
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| Format: | Book |
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Weinheim
Wiley-VCH
2013
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Table of Contents:
- A chemist's survey of different antibiotic classes
- Antibacterial discovery: problems and possibilities
- Impact of microbial natural products on antibacterial drug discovery
- Antibiotics and resistance: a fatal attraction
- Fitness costs of antibiotic resistance
- Inhibitors of cell-wall synthesis
- Inhibitors of bacetrial cell partitioning
- The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens
- Bacterial membrane, a key for controlling drug influx and efflux
- Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives
- Recent developments in inhibitors of bacterial type IIA topoisomerases
- Antibiotics targeting bacterial RNA polymerase
- Inhibitors targeting riboswitches and ribozymes
- Targeting ribonuclease P
- Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery
- Aminoacyl-tRNA synthetase inhibitors
- Antibiotics targeting translation initiation in prokaryotes
- Inhibitors of bacterial elongation factor EF-Tu
- Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site
- Reptidyltransferase inhibitors of the bacterial ribosome
- Antibiotics inhibiting the translocation step of protein elongation on the ribosome
- Antibiotics at the ribosomal exit tunnel--selected structual aspects
- Targeting HSP70 to fight cancer and bad bugs: one and the same battle?
ANTIBIOTICS CHALLENGES MECHANISMS OPPORTUNITIES