Peptidomimetics in organic and medicinal chemistry
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimet...
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Chichester, West Sussex, United Kingdom
John Wiley & Sons Inc.
2014
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| Online Access: | Click Here to View Status and Holdings. |
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| LEADER | 00000n a2200000 a 4501 | ||
|---|---|---|---|
| 001 | wils-523925 | ||
| 020 | # | # | |a 9781119950608 (hbk.) |
| 040 | # | # | |a DLC |d ITMB |
| 060 | 0 | 0 | |a QV 745 |
| 090 | 0 | 0 | |a QV745 |b T758p 2014 |
| 100 | 1 | # | |a Trabocchi, Andrea |
| 245 | 1 | 0 | |a Peptidomimetics in organic and medicinal chemistry |c Dr Andrea Trabocchi and Professor Antonio Guarna |
| 260 | # | # | |a Chichester, West Sussex, United Kingdom |b John Wiley & Sons Inc. |c 2014 |
| 300 | # | # | |a xix, 288 p. |b ill. (10 unnumbered pages of plate) |c 25 cm |
| 504 | # | # | |a Includes bibliographical references and index |
| 520 | # | # | |a "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery" |
| 520 | # | # | |a "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature" |
| 650 | # | 0 | |a Drug Design |
| 650 | # | 0 | |a Peptidomimetics |x therapeutic use |
| 650 | # | 0 | |a Peptidomimetics |x metabolism |
| 700 | 1 | # | |a Guarna, Antonio |
| 856 | 4 | 0 | |z Click Here to View Status and Holdings. |u https://opac.uitm.edu.my/opac/detailsPage/detailsHome.jsp?tid=523925 |
| 964 | # | # | |c BOK |d PH |
MEDICINAL CHEMISTRY