New developments on signal transduction research

• Other Authors: Yamaguchi, Masayoshi 1947- (Editor)
• Format: Book
• Language: English
• Published: New York Nova Biomedical 2013
• Series: Cell biology research progress
• Subjects: Cellular signal transduction; Cell interaction
• Online Access: Click Here to View Status and Holdings.
• Physical Description: x, 220 pages illustrations 26 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9781626182301; 1626182302

Signal transduction plays a pivotal role in cell regulation. Hormones, cytokines and neurotransmitters bind to their specific receptors in the plasma membranes of cells. The receptors of many hormones are coupled to G-protein coupled signalling pathways. Insulin and growth factors are coupled to receptor-linked kinase. The second messenger is generated in cells once the first messenger binds to the receptors of plasma membranes. Cyclic adenosine monophosphate (cyclic AMP), inositol 1,3,5-triphosphate (IP3) and calcium ion (Ca2+) have been demonstrated to play a role as a second messenger in cells. The pivotal role of Ca2+ in cellular regulation was established with the finding of calmodulin and protein kinase C that modulates the effect of Ca2+ in the regulation of cellular functions. Many receptor classes and their downstream kinases activate Erk, Akt, Stat, Smad, NF- B and other cascades to regulate gene expression and cellular function. This book provides recent research in the study of the new developments in signalling transduction in cells