Cardiac drug safety a bench to bedside approach

• Main Author: Killeen, Matthew J. (Author)
• Format: Book
• Language: English
• Published: New Jersey World Scientific Publishing 2012
• Subjects: Anti-Arrhythmia Agents > toxicity; Anti-Arrhythmia Agents > adverse effects; Arrhythmias, Cardiac > drug therapy
• Online Access: Click Here to View Status and Holdings.

Ensuring the safety of new medical products remains a major challenge for the pharmaceutical industry. Cardiac safety, particularly drug-induced heart rhythm abnormalities, remains an important cause of pipeline attrition and has resulted in countless major product recalls or label changes. The risk...

Table of Contents:

• Challenges facing the pharmaceutical industry in the 21st century
• The cellular basis of cardiac electrophysiology
• Clinical arrhythmia syndromes
• The mechanisms underlying cardiac arrhythmias
• The mechanisms underlying drug-induced arrhythmias
• Assessing cardiac safety in drug development
• Pediatric cardiac safety
• Drug-induced atrial fibrillation
• Navigating the future path of cardiac drug safety.