GPCR signalling complexes synthesis, assembly, trafficking and specificity
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners...
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| Other Authors: | , , |
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| Format: | Book |
| Language: | English |
| Published: |
Dordrecht
Springer
2012
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| Series: | Sub-cellular biochemistry
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| Subjects: | |
| Online Access: | Click Here to View Status and Holdings. |
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| 245 | 0 | 0 | |a GPCR signalling complexes |b synthesis, assembly, trafficking and specificity |c Denis J. Dupré, Terence E. Hébert, Ralf Jockers, editors. |
| 264 | # | 1 | |a Dordrecht |b Springer |c 2012 |
| 264 | # | 4 | |c ©2012 |
| 300 | # | # | |a viii, 299 pages |b illustrations (some colour) |c 24 cm |
| 336 | # | # | |a text |b txt |2 rdacontent |
| 337 | # | # | |a unmediated |b n |2 rdamedia |
| 338 | # | # | |a volume |b nc |2 rdacarrier |
| 490 | 1 | # | |a Subcellular biochemistry |v volume 63 |x 0306-0225 |
| 504 | # | # | |a Includes bibliographical references and index |
| 505 | 0 | # | |t ER-bound steps in the biosynthesis of G protein-coupled receptors / $rChristian Nanoff and Michael Freissmuth -- $tRole of chaperones in G Protein coupled receptor signaling complex assembly / $rDenis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman -- $tGPCR oligomerization: contribution to receptor biogenesis / $rKathleen Van Craenenbroeck -- $tThe functional size of GPCRs: monomers, dimers or tetramers? / $rDarlaine Pétrin and Terence E. Hébert -- $tRegulation of post-Golgi traffic of G protein-coupled receptors / $rGuangyu Wu -- $tRegulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example / $rHamasseh Shirvani, Gabriel Gätà and Stefano Marullo -- $tRegulatory processes governing the cell surface expression of LH and FSH receptors / $rDeborah L. Segaloff -- $tChaperone-mediated assembly of G protein complexes / $rBarry M. Willardson and Christopher M. Tracy -- $tSynthesis and assembly of G protein [beta][gamma] dimers: comparison of in vitro and in vivo studies / $rJane Dingus and John D. Hildebrandt -- $tPreferential assembly of G-[alpha][beta][gamma] complexes directed by the [gamma] subunits / $rJanet D. Robishaw -- $tG Protein trafficking / $rPhilip B. Wedegaertner -- $tDifferential assembly of GPCR signaling complexes determines signaling specificity / $rPascal Maurice, Abla Benleulmi-Chaachoua and Ralf Jockers -- $tGPCR and voltage-gated calcium channels (VGCC) signaling complexes / $rChristophe Altier -- $tPharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target / $rGuadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick and P. Michael Conn. |
| 520 | # | # | |a Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question |
| 650 | 1 | 2 | |a Receptors, G-Protein-Coupled |x biosynthesis |
| 650 | 1 | 2 | |a Receptors, G-Protein-Coupled |x chemistry |
| 650 | 2 | 2 | |a Receptors, G-Protein-Coupled |x metabolism |
| 650 | 2 | 2 | |a Signal Transduction |
| 700 | 1 | # | |a Dupré, Denis J. |e editor |
| 700 | 1 | # | |a Hébert, Terence E. |e editor |
| 700 | 1 | # | |a Jockers, Ralf |e editor |
| 830 | # | 1 | |a Sub-cellular biochemistry |s ub-cellular biochemistr |
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Pharmacology of G protein coupled receptors