Antimicrobial drug discovery emerging strategies

• Other Authors: Tegos, George (Editor), Mylonakis, Eleftherios (Editor)
• Format: Book
• Language: English
• Published: Wallingford, Oxfordshire CABI 2012
• Series: Advances in molecular and cellular microbiology 22
• Subjects: Anti-Infective Agents > pharmacology; Drug Design; Disease Models, Animal; High-Throughput Screening Assays > methods; Photosensitizing Agents > pharmacology
• Online Access: Click Here to View Status and Holdings.
• Physical Description: x, 357 pages illustrations 25 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9781845939434; 1845939433

Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies