DNA repair in cancer therapy molecular targets and clinical applications

• Other Authors: Kelley, Mark Richard 1957- (Editor)
• Format: Book
• Language: English
• Published: London Elsevier/Academic Press 2012
• Subjects: Neoplasms > drug therapy; DNA Repair; Neoplasms > genetics
• Online Access: Click Here to View Status and Holdings.
• Physical Description: xiii, 316 pages illustrations 29 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9780123849991; 0123849993

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation. This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment