Gene transfer and the ethics of first-in-human research lost in translation

• Main Author: Kimmelman, Jonathan (Author)
• Format: Book
• Language: English
• Published: Cambridge, UK Cambridge University Press 2010
• Subjects: Gene Transfer Techniques > ethics; Human Experimentation > ethics; Public Policy
• Online Access: Click Here to View Status and Holdings.
• Physical Description: xi, 205 pages illustrations 24 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9780521690843; 0521690846

"Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions"--Provided by publisher.