Methods for the discovery and characterization of G protein-coupled receptors

• Other Authors: Stevens, Craig W. (Editor)
• Format: Book
• Language: English
• Published: New York Humana Press 2011
• Series: Neuromethods; Springer protocols
• Subjects: GTP-Binding Proteins; Receptors, G-Protein-Coupled
• Online Access: Click Here to View Status and Holdings.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts...

Table of Contents:

• In silico identification of novel G protein-coupled receptors / |r Matthew N. Davies, David E. Gloriam, and Darren R. Flower
• |t Alternative pre-mRNA splicing of G protein-coupled receptors / |r Ying-Xian Pan, Steven Grinnell, and Gavril W. Pasternak
• |t Detecting polymorphisms in G protein-coupled receptor genes / |r Dmitri Proudnikov, Vadim Yuferov, and Mary Jeanne Kreek
• |t Regulation of the transcription of G protein-coupled receptor genes / |r Cheol Kyu Hwang ... [et al.]
• |t Deciphering the evolution of G protein-coupled receptors in vertebrates / |r Craig W. Stevens
• |t New approach to visualize endogenously expressed G protein-coupled receptors in tissues and living cells / |r Gregory Scherrer and Brigitte L. Kieffer
• |t Posttranslational regulation of G protein-coupled receptors / |r Yu Qiu and Ping-Yee Law
• |t Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum / |r Chunmin Dong and Guangyu Wu
• |t Identifying G protein-coupled receptor escorts, chaperones, and intracellular tethers regulating receptor density at the cell surface / |r Stefano Marullo, Liliana Pardo Lopez, and Lamia Achour
• |t Novel method for determining the kinetics of G protein-coupled receptor plasma membrane expression / |r Gregory W. Sawyer
• |t Characterizing the pharmacology of G protein-coupled receptors in transfected cell lines / |r Kathryn A. Seely and Paul L. Prather
• |t Novel assay technologies for the discovery of G protein-coupled receptor drugs / |r Elisa Alvarez-Curto, Richard J. Ward, and Graeme Milligan
• |t Discovering cell type-specific patterns of G protein-coupled receptor phosphorylation / |r Kok Choi Kong, Andrew B. Tobin, and Adrian J. Butcher
• |t Quantifying allosteric modulation of G protein-coupled receptors / |r Frederick J. Ehlert and Hinako Suga
• |t Experimental designs for the study of receptor-receptor interactions / |r Dennis Paul
• |t Elucidating agonist-selective mechanisms of G protein-coupled receptor desensitization / |r Chris P. Bailey and Eamonn Kelly
• |t Detecting the role of arrestins in G protein-coupled receptor regulation / |r Laura M. Bohn and Patricia H. McDonald
• |t Characterizing molecular mobility and membrane interactions of G protein-coupled receptors / |r Vladana Vukojevice, Yu Ming, and Lars Terenius
• |t Using RNA interference to downregulate G protein-coupled receptors / |r Philippe Sarret ... [et al.]
• |t Upregulating G protein-coupled receptors with receptor antagonists / |r Ellen M. Unterwald.