Methods for the discovery and characterization of G protein-coupled receptors
The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts...
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| Format: | Book |
| Language: | English |
| Published: |
New York
Humana Press
2011
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| Series: | Neuromethods
Springer protocols |
| Subjects: | |
| Online Access: | Click Here to View Status and Holdings. |
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| 245 | 0 | 0 | |a Methods for the discovery and characterization of G protein-coupled receptors |c edited by Craig W. Stevens |
| 264 | # | 1 | |a New York |b Humana Press |c 2011 |
| 264 | # | 4 | |c ©2011 |
| 300 | # | # | |a xiii, 428 pages |b illustrations |c 26 cm |
| 336 | # | # | |a text |b txt |2 rdacontent |
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| 490 | 1 | # | |a Neuromethods |v 60 |x 0893-2336 |
| 490 | # | # | |a Springer protocols |
| 504 | # | # | |a Includes bibliographical references and index |
| 505 | 0 | # | |a In silico identification of novel G protein-coupled receptors / |r Matthew N. Davies, David E. Gloriam, and Darren R. Flower -- |t Alternative pre-mRNA splicing of G protein-coupled receptors / |r Ying-Xian Pan, Steven Grinnell, and Gavril W. Pasternak -- |t Detecting polymorphisms in G protein-coupled receptor genes / |r Dmitri Proudnikov, Vadim Yuferov, and Mary Jeanne Kreek -- |t Regulation of the transcription of G protein-coupled receptor genes / |r Cheol Kyu Hwang ... [et al.] -- |t Deciphering the evolution of G protein-coupled receptors in vertebrates / |r Craig W. Stevens -- |t New approach to visualize endogenously expressed G protein-coupled receptors in tissues and living cells / |r Gregory Scherrer and Brigitte L. Kieffer -- |t Posttranslational regulation of G protein-coupled receptors / |r Yu Qiu and Ping-Yee Law -- |t Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum / |r Chunmin Dong and Guangyu Wu -- |t Identifying G protein-coupled receptor escorts, chaperones, and intracellular tethers regulating receptor density at the cell surface / |r Stefano Marullo, Liliana Pardo Lopez, and Lamia Achour -- |t Novel method for determining the kinetics of G protein-coupled receptor plasma membrane expression / |r Gregory W. Sawyer -- |t Characterizing the pharmacology of G protein-coupled receptors in transfected cell lines / |r Kathryn A. Seely and Paul L. Prather -- |t Novel assay technologies for the discovery of G protein-coupled receptor drugs / |r Elisa Alvarez-Curto, Richard J. Ward, and Graeme Milligan -- |t Discovering cell type-specific patterns of G protein-coupled receptor phosphorylation / |r Kok Choi Kong, Andrew B. Tobin, and Adrian J. Butcher -- |t Quantifying allosteric modulation of G protein-coupled receptors / |r Frederick J. Ehlert and Hinako Suga -- |t Experimental designs for the study of receptor-receptor interactions / |r Dennis Paul -- |t Elucidating agonist-selective mechanisms of G protein-coupled receptor desensitization / |r Chris P. Bailey and Eamonn Kelly -- |t Detecting the role of arrestins in G protein-coupled receptor regulation / |r Laura M. Bohn and Patricia H. McDonald -- |t Characterizing molecular mobility and membrane interactions of G protein-coupled receptors / |r Vladana Vukojevice, Yu Ming, and Lars Terenius -- |t Using RNA interference to downregulate G protein-coupled receptors / |r Philippe Sarret ... [et al.] -- |t Upregulating G protein-coupled receptors with receptor antagonists / |r Ellen M. Unterwald. |
| 520 | # | # | |a The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called "Future Directions" which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors |
| 650 | 1 | 2 | |a GTP-Binding Proteins |
| 650 | 2 | 2 | |a Receptors, G-Protein-Coupled |
| 700 | 1 | # | |a Stevens, Craig W. |e editor |
| 830 | # | 1 | |a Neuromethods |
| 830 | # | # | |a Springer protocols |
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Pharmacology of G protein coupled receptors