Breast cancer a Lobar disease

• Other Authors: Tot, Tibor
• Format: Book
• Published: London Springer 2011
• Subjects: Breast Neoplasms > genetics; Breast Neoplasms > etiology; Breast Neoplasms > pathology; Breast > Cancer
• Online Access: Click Here to View Status and Holdings.

The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, develo...

Table of Contents:

• The theory of the sick lobe
• Lobar anatomy of human breast and its importance for breast cancer
• Breast cancer may originate in utero: the importance of the intrauterine environment for breast cancer development
• Genetic alterations in normal and malignant breast tissue
• The role of ductal lavage: a cautionary tale
• The distribution of the earliest forms of breast carcinoma
• The implications of the imaging manifestations of multifocal and diffuse breast cancers
• Lobar ultrasound of the breast
• The lobar distribution of the lesions in breast carcinoma: ductoscopy and surgery
• Strop breast cancer now!: imagining imaging pathways towards search, destroy, cure, and watchful waiting of premetastasis breast cancer
• Epilogue: the diseased breast lobe in the context of X-chromosome inactivation and differentiation waves.