Hepatotoxicity from genomics to in vitro and in vivo models

• Other Authors: Sahu, Saura C (Editor)
• Format: Book
• Language: English
• Published: Chichester, West Sussex John Wiley & Sons ©2007
• Subjects: Drug-Induced Liver Injury > etiology; Drug Evaluation, Preclinical; Liver > drug effects
• Online Access: Click Here to View Status and Holdings.
• Physical Description: xvi, 682 p. ill. 25 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9780470057162; 0470057165

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science