Disorders of hemoglobin genetics, pathophysiology, and clinical management

• Other Authors: Steinberg, Martin H. (Editor), Forget, Bernard G. (Editor), Higgs, Douglas R. (Editor), Weatherall, David J. (Editor)
• Format: Book
• Language: English
• Published: Cambridge Cambridge University Press 2009
• Edition: Second Edition
• Subjects: Hemoglobinopathies > genetics; Hemoglobinopathies > physiopathology; Hemoglobinopathies > therapy
• Online Access: Click Here to View Status and Holdings.
• Physical Description: xx, 826 pages illustrations 29 cm
• Bibliography: Includes bibliographical references and index
• ISBN: 9780521875196; 0521875196

This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with and thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy