Nitrosamines toxicology and microbiology

• Other Authors: Hill, Michael J. 1939- (Editor)
• Format: Book
• Language: English
• Published: Chichester, England Ellis Horwood 1988
• Subjects: Nitrosamines
• Online Access: Click Here to View Status and Holdings.
• Item Description: Includes bibliographical references and index
• Physical Description: 169 pages illustrations 24 cm
• ISBN: 9783527267088; 3527267085; 9780895736055; 0895736055; 9780895736505; 0895736500

Interest in the role of N-nitroso compounds in human cancer has magnified due to the widespread use of these compounds in all branches of carcinogenesis research. Here, a knowledge of the chemistry of N-nitrosation is necessary in order to understand the association between N-nitrosamines and human disease. This book opens with a discussion of the problems associated with the analysis of volatile N-nitrosamines, of the various groups of non-volatile N-nitroso compounds and of the apparent total N-nitroso compounds. This is followed by chapters on the chemistry of N-nitroso compounds and of N-nitrosation, on the mechanisms of the endogenous formation of N-nitroso compounds and on the occurrence of N-nitroso-amines and their precursors in the human environment. The next chapter reviews the toxicology of N-nitroso compounds in animals or in vitro assay systems considering acute and chronic toxicity, carcinogenicity and teratogenicity of N-nitroso-peptides and N-nitroso bile acids. The penultimate chapter deals with the evidence implicating N-nitroso compounds in human cancer, particularly of the stomach and urinary bladder but also of other sites